GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4950322 | 1 | rs61230354 | chr1:146869891 | FMO5 | chr1:146655885-146697230:- | 0.24 | 3.87 | 0.000125 | Protein quantitative trait loci |
| THCA | cis | rs6021270 | 1 | rs6123048 | chr20:50147400 | ATP9A | chr20:50213314-50384908:- | -0.24 | -4.09 | 5.1E-5 | Self-reported allergy |
| THCA | cis | rs2129782 | 1 | rs61234864 | chr8:89445857 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs6012564 | 1 | rs6125539 | chr20:47703810 | ARFGEF2 | chr20:47538275-47653229:+ | -0.12 | -3.59 | 0.000368 | Anger |
| THCA | cis | rs6012564 | 1 | rs6125539 | chr20:47703810 | CSE1L | chr20:47662838-47713484:+ | 0.41 | 9.78 | 1.07E-20 | Anger |
| THCA | cis | rs6012564 | 1 | rs6125540 | chr20:47704039 | ARFGEF2 | chr20:47538275-47653229:+ | -0.13 | -4.31 | 1.95E-5 | Anger |
| THCA | cis | rs6012564 | 1 | rs6125540 | chr20:47704039 | CSE1L | chr20:47662838-47713484:+ | 0.38 | 9.46 | 1.36E-19 | Anger |
| THCA | cis | rs6012564 | 1 | rs6125576 | chr20:47776919 | ARFGEF2 | chr20:47538275-47653229:+ | -0.11 | -3.48 | 0.000539 | Anger |
| THCA | cis | rs6012564 | 1 | rs6125576 | chr20:47776919 | CSE1L | chr20:47662838-47713484:+ | 0.4 | 9.74 | 1.49E-20 | Anger |
| THCA | cis | rs6063399 | 1 | rs6125643 | chr20:48012538 | KCNB1 | chr20:47988505-48100490:- | -0.16 | -3.43 | 0.000666 | Obesity-related traits |
| THCA | cis | rs6021270 | 1 | rs6126249 | chr20:50142623 | ATP9A | chr20:50213314-50384908:- | -0.24 | -3.7 | 0.00024 | Self-reported allergy |
| THCA | cis | rs8030605 | 1 | rs61270078 | chr15:56478983 | MNS1 | chr15:56720929-56757335:- | -0.24 | -3.56 | 0.000414 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs8030605 | 1 | rs61270078 | chr15:56478983 | TEX9 | chr15:56657644-56738071:+ | -0.35 | -6.03 | 3.21E-9 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs7714584 | 1 | rs61270113 | chr5:150226263 | LOC134466 | chr5:150310000-150326146:- | 0.38 | 5.23 | 2.51E-7 | Crohn's disease |
| THCA | cis | rs6127978 | 1 | rs6127978 | chr20:55819173 | BMP7 | chr20:55743809-55841707:- | -0.21 | -3.94 | 9.32E-5 | Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder |